Pharma e-commerce in the United States – statistics & facts

The United States leads the global online pharmacy market, with annual revenues exceeding 20 billion U.S. dollars. The COVID-19 pandemic catapulted revenue growth in the digital health market’s online pharmacy sector. Although the growth slowed post-pandemic, it still propelled the industry towards greater digital adoption, with an estimated 68 million individuals expected to purchase their over-the counter (OTC) medicine online in 2024. This number is forecast to rise to around 79 million by 2029, indicating a steadily growing industry.
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Published by Xin Ou, Dec 17, 2025

Key insights

Total OTC drug retail sales in the U.S. in 2024
****bn USD
Online pharmacy revenue in the U.S.
**bn USD
Country with the highest online pharmacy revenue
United States

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Current statistics on this topic

Top online stores in the pharmacy segment in the United States in 2023, by e-commerce net sales (in million U.S. dollar)

B2C E-Commerce

Top online stores in the pharmacy segment in the U.S. 2023, by net sales

Leading pharmacies in the United States in 2024, based on prescription revenue (in billion U.S. dollars)

Pharmacies

Leading pharmacies in the U.S. 2024, based on prescription revenue

Monthly retail sales of pharmacies and drug stores in the United States from 2017 to 2025 (in million U.S. dollars)

Drugstores & Perfumeries

Pharmacy and drug store monthly sales in the U.S. 2017 to 2025

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Overview

5

Overview

Key figures

6

Key figures

Leading players

4

Leading players

Brand awareness

5

Brand awareness

Online traffic & downloads

6

Online traffic & downloads

Consumer behavior

9

Consumer behavior

Further reports

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E-commerce in the United States
E-commerce in the United States
Health in U.S. states
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Out-of-pocket health care spending in the U.S.
Out-of-pocket health care spending in the U.S.
Pharma e-commerce
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Trust in healthcare in the U.S.
Trust in healthcare in the U.S.
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